STRUCTURAL REQUIREMENTS FOR DIABETOGENIC ACTION IN ALLOXAN AND RELATED COMPOUNDS

Diabetogenic Action of Alloxan on Liver Histopathology

The cytotoxic alloxan is the most prominent diabetogenic chemical agent in experimental diabetes research. Alloxan has been found to be selectively toxic to liver hepatocytes. The experiments aim to understand the effect of alloxan on cytomorphology of liver in rat. Treatment with alloxan caused central vein congestion with significant dilatation of sinusoidal spaces. The liver of the alloxan t...

Hemolysis with alloxan and alloxan-like compounds, and the protective action of tocopherol.

Structural and redox requirements for the action of anti-diabetic vanadium compounds.

This study presents the first systematic investigation of the anti-diabetic properties of non-oxido V(IV) complexes. In particular, the insulin-mimetic activity of [V(IV)(taci)2](4+), [V(IV)(inoH-3)2](2-), [V(IV)(dhab)2], [V(IV)(hyph(Ph))2], [V(IV)(cat)3](2-) and [V(IV)(pdbh)2]--where taci is 1,3,5-triamino-1,3,5-trideoxy-cis-inositol, ino is cis-inositol, H2dhab is 2,2'-dihydroxyazobenzene, H2...

passivity in waiting for godot and endgame: a psychoanalytic reading

this study intends to investigate samuel beckett’s waiting for godot and endgame under the lacanian psychoanalysis. it begins by explaining the most important concepts of lacanian psychoanalysis. the beckettian characters are studied regarding their state of unconscious, and not the state of consciousness as is common in most beckett studies. according to lacan, language plays the sole role in ...

Testicular action and structural relationships of compounds with antiatherogenic activity.

IN A STUDY comparing the antiatherogenic action of estradiol-17a and of estradiol-17/? in cholesterol-fed chickens, it was observed that, although both isomers were able to induce testicular atrophy at the dosage used, only estradiol-17/3 prevented coronary atherosclerosis j 1 2 similarly, in men active estrogens but not estradiol-17a are able to influence blood lipids. The mechanisms involved ...